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6-fold resistant to crenolanib
SB-705498 is an orally bioavailable
Chemical Name: propan-2-yl (2S)-2-{[(S)-({[(2R)-1-(6-amino-9H-purin-9-yl)propan-2-yl]oxy}methyl)(phenoxy)phosphoryl]amino}propanoate
InChiKey: TUIHIKXCMCXXJG-UHFFFAOYSA-N
Panobinostat abolite Omeprazole sulfone 6-fold resistant to crenolanibPanobinostat, also known as NVP LBH 589 or LBH 589, is a cinnamic hydroxamic acid analogue with potential antineoplastic activity. Panobinostat selectively inhibits histone deacetylase (HDAC), inducing hyperacetylation of core histone proteins, which may result in modulation of cell cycle protein expression, cell cycle arrest in the G2 M phase and apoptosis. In addition, this agent appears to modulate the expression of angiogenesis related genes, such
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