PD0325901 - MEK Inhibitor. CAS#391210-10-9 60087 that converge on phosphorylating the

that converge on phosphorylating the α-subunit of initiation factor 2 (eIF2α )

D-2-Hydroxypentanedioic acid disodium salt

Smiles: ONC(=O)C1CCCC=1

CAS Number: 761439-42-3

PD0325901 - MEK Inhibitor. CAS#391210-10-9 60087 that converge on phosphorylating thePD0325901, CAS No. 391210 10 9, is a highly potent and selective inhibitor of MEK with an IC50 of 0. 33 nM. Its potency, selectivity, and solubility are all better than many other MEK inhibitors (e. g., CI 1040). It can potently inhibit the phosphorylation and activation of MAPK ERK and tumor cell proliferation. In combination with CHIR99021, PD0325901 has been shown to promote mouse ES cell self renewal and iPSC generation. Product information CAS