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ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25
24)/t17-/m0/s1
and the CG is approximately 20 times less than Vabicaserin based on steady-state AUC0-24 values
4-difluorophenyl)-1-(2
EL-102 islignan ClH/c22-20-8-6-19(7-9-20)21(18-4-2-1-3-5-18)24-12-10-23(11-13-24)14-16-26-17-15-25EL102 is a inhibitor of HIF1 , Which can inhibit tubulin polymerisation and decreased microtubule stability. target: HIF1IC 5020 40 nM. in vitro : EL102 is a cytotoxic agent and also displays cytostatic properties, through flow cytometric analysis of PI stained cells cultured for 24, 48 and 72 h, following treatment. EL102 induces apoptosis and causes G2 M arrest, preventing the cell from entering into mitosis. In vivo: CWR22 tumours were taken from