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Some of the drugs most commonly associated with this syndrome include: Anticonvulsants (like phenytoin, carbamazepine) Allopurinol Sulfonamides Antipsychotics Antibiotics (like minocycline) Antiretroviral drugs The exact reason why some individuals develop DRESS Syndrome is not fully understood, but it seems to involve a complex interaction between drug metabolism, viral reactivation, and the immune system