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or HIF-1α/HIF-1β heterodimerization in nuclei under the hypoxic conditions
It inhibits hypoxia-induced HIF-1α transcriptional activity without suppressing HIF-1α mRNA expression
N-cyclopropyl-4-[7-[[(cis-3-hydroxy-3-methylcyclobutyl)methyl]amino]-5-(3-pyridinyloxy)pyrazolo[1
InChi: InChI=1S/C20H25N3O2/c1-15-10-12-16(13-11-15)20(25)22-14-6-2-3-9-19(24)23-18-8-5-4-7-17(18)21/h4-5
Felbamate - CAS# 25451-15-4 size:10mg solid or HIF-1α/HIF-1β heterodimerization in nucleiFelbamate, CAS No. 25451 15 4, is an anti epileptic drug used in the treatment of epilepsy. Felbamate has been proposed to a unique dual mechanism of action as a positive modulator of GABAA receptors and as a blocker of NMDA receptors, particularly isoforms containing the NR2B subunit. Although it is clear that felbamate does cause pharmacological inhibition of NMDA receptors, the relevance of NMDA receptor blockade as a strategy for the treatment of
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