HIF-C2 - HIF-2 Inhibitor. CAS# 1422955-31-4 Catalog No.:M60121-2S 3)-dioxygenase) pathway inhibitor with Ki

3)-dioxygenase) pathway inhibitor with Ki ~7 nM (EC50 ~75 nM) in vitro and in cell based assays

KDM5-C49 was used at 1-10 µM in vitro

4)16(20)15(26)17(28-12(2)23)21(22

and acceptable predicted human clearance after incorporating both CYP- and AO-mediated metabolism

HIF-C2 - HIF-2 Inhibitor. CAS# 1422955-31-4 Catalog No.:M60121-2S 3)-dioxygenase) pathway inhibitor with KiHIF C2, CAS No. 1422955 31 4, is a potent and selective allosteric inhibitor of hypoxia inducible factor 2 (HIF 2). It binds within the internal cavity of HIF 2 PAS B (Kd of 81 nM) and disrupts heterodimerization of the full length HIF 2 transcription factor. HIF C2 functions effectively as a HIF 2 inhibitor in living cells, disrupting HIF 2 DNA binding and inhibiting the transcription of its target genes. Moreover, HIF C2 is selective for the HIF 2