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stimulates IFN signals in mice
and a 20-fold decrease in potency as a Cdk antagonist
InChi: InChI=1S/C29H27F5N2O6S/c1-35(43(41
25 mg/mL (85
Org 25543 hydrochloride ine trihydrochloride stimulates IFN signals in miceIC50: 16 nM Org 25543 hydrochloride is a potent and selective glycine transporter type 2 (GlyT2) inhibitor for hGlyT2. Two major subtypes of glycine transporter are type 1 (GlyT 1) and type 2 (GlyT 2) revealed by molecular cloning. The GlyT 2 transporter has a similar distribution to ssGlyR with being confined to the spinal cord and brain stem, whereas the GlyT 1 transporter has a wide distribution throughout the CNS. In vitro: Org 25543 was
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