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24 hours) exhibits general cytostatic but type-specific cytotoxic effects for melanoma cells
) dose-dependently increases serum ApoA1 protein levels and low-density lipoprotein-cholesterol (LDLc) levels in mice
Treatment of cells with SSE15206 causes aberrant mitosis resulting in G2/M arrest due to incomplete spindle formation
Parkinson’s disease
CFI-400945 rexol 24 hours) exhibits general cytostaticCFI 400945 is an orally active, potent and selective inhibitor of polo like kinase 4. Polo like kinase 4 (PLK4), a unique member of the Polo like family of kinases, shares little homology with other polo like kinases. PLK4 plays an essential role in centriole duplication. Overexpression of PLK4 overrides the centriole licensing mechanism and results in centriole amplification with multiple procentrioles forming around each parental centriole.