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000-fold selectivity for PHD2 over other 2OG-dependent dioxygenases
4]oxazepin-4(5H)-yl)propan-1-one
injections of 40 mg/kg/day canertinib (Fig
A specific inhibitor of phosphatidylinositol 3-kinase
PYR-41 - Ubiquitin-activating Enzyme E1 Inhibitor. CAS# 418805-02-4 Catalog No.:M60201-10S 000-fold selectivity for PHD2 overPYR 41, CAS No. 418805 02 4, is a ubiquitin activating enzyme inhibitor (UBE1 inhibitor). PYR 41 blocks ubiquitination reactions but paradoxically leads to the accumulation of high MW ubiquitinated proteins. PYR 41 also mediated cross linking of specific protein kinases (Bcr Abl, Jak2) to inhibit their signaling activity. PYR 41 has demonstrated anti tumor activity in animal studies, partially selective protein cross linking may represent an alternate
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