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Background Known as DRESS syndrome A severe adverse drug reaction Usually begins within 8 weeks of starting a new drug 8-10% mortality Previously known as Dilantin Hypersensitivity Syndrome or Anti-convulsant hypersensitivity syndrome However, many other medications, particularly antibiotics A virus-drug interaction with HHV-6, HHV-7, EBV, and CMV may be a form of pathogenesis as well [1] Associated Drugs Most common Phenytoin Phenobarbital Carbamazepine Allopurinol Sulfa drugs Others NSAIDS Anti-retrovirals ACE inhibitors Calcium-channel blockers Atypical antipsychotics (ziprasidone, olanzapine, etc.) [2] Other antibiotics Clinical Features Fever and rash (varying