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In addition, as shown in the two cases presented and reported in others.4,8,9 the strong association between DRESS and HHV-6 reactivation points to a complex interaction among virus, antiviral immunity and drug-specific immune responses.4,8 This association seems to be disease-specific, as other drug reactions are not related to HHV-6 reactivation, and has led some investigators to propose the term drug-induced hypersensitivity syndrome (DIHS), highlighting the importance of HHV-6 reactivation in their diagnostic criteria.10,11 Nevertheless, a recent report12 suggests that certain drugs may stimulate a massive expansion of drug specific cytotoxic T cells that destroy hepatocytes via a cell-contact-dependent mechanism

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All I know is that after more than twenty years in Japan, it still feels special