CPI-637 - CAS# 1884712-47-3 60010 which targets only mTORC1

which targets only mTORC1

Montich GG

Chemical Name:  (R)-4-methyl-6-(1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl)-1

Mirdametinib

CPI-637 - CAS# 1884712-47-3 60010 which targets only mTORC1CPI 637, CAS No. 1884712 47 3, is a potent and selective CBP EP300 bromodomain inhibitor. The biochemical potency of CPI 637 translated well into cells (CBP BRET EC50 = 0. 3 M). CPI 637 demonstrated a >700 fold selectivity over the BET family of bromodomains (BRD4 IC50 = 11. 0 0. 6 M). CPI 637 inhibits MYC expression in AMO 1 cells (EC50 = 0. 60 M). CBP and EP300 are highly homologous, bromodomain containing transcription coactivators involved in