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(2006) Proc Amer Assoc Cancer Res
orally bioavailable inhibitor of class I PI3 kinase for the treatment of cancer
1020149-73-8
Smiles: CC1C=C(C)C(=CC=1)N(/N=C/C1C=C(C=CC=1)OC)C(=O)C(F)(F)F
L002 (NSC764414) - p300 Inhibitor. CAS# 321695-57-2 Catalog No.:M60198-10S (2006) Proc Amer Assoc CancerL002 (NSC764414), CAS No. 321695 57 2, is a novel selective, cell permeable and reversible inhibitor of p300 histone acetyl transferase (IC50 ~1. 98 M). It has no activity in histone methyltransferases tested, including DOT1, EZH1, G9a, PRMT1, SETD2, SET7 9, SMYD2, and SUV39H2 etc. L002 was shown to occupy Ac CoA binding pocket of p300, and is less potent to CBP, PCAF, GCN5 and GNAT. It suppresses Histone H3 and H4 acetylation in triple negative
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