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9)10/h2-16H
PubMed Central PMCID: PMC3701049
Chemical Name: 2-(7-chloro-4-oxo-3
890190-22-4
GDC-0941 - PI3K Inhibitor. CAS# 957054-30-7 size:2 mg solid 9)10/h2-16HGDC 0941, CAS No. 957054 30 7, is a highly potent, selective and orally bioavailable class I PI3K kinase inhibitor. Its IC50 for PI3K p110 , , and isoforms are 3 nM, 33 nM, 3 nM, and 75 nM, respectively; and its IC50 for DNA PK and mTOR are 1230 nM and 580 nM. It potently inhibits the phosphorylation of Akt in U87MG, PC3, and MDA MB 361 cells with IC50 of 46 nM, 37 nM, and 28 nM, respectively. It also inhibits the proliferation of U87MG, A2780, PC3,
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