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reverts such resistance
Molecular Weight: 572
but not the leukotriene D4-induced bronchoconstriction
Formula: C39H65N5O8
PHA-793887 )hydrazono)butane-1 3-dione reverts such resistancePHA 793887 is an inhibitor of multiple cyclin dependent kinases (CDK) with activity against CDK2, CDK1 and CDK4. PHA 793887 was cytotoxic for leukemic cell lines in vitro, with IC(50) ranging from 0. 3 to 7 microM. In colony assays PHA 793887 showed very high activity against leukemia cell lines, with an IC(50) <0. 1 microM indicating that it has efficient and prolonged antiproliferative activity. PHA 793887 induced cell cycle arrest, inhibited Rb and