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Receptor occupation and pharmacokinetics of MPC-1304
40-octakis(hydroxymethyl)-2
Formula: C34H32MnN4O4
Formula: C19H24ClN3O
SR 1824 Catalog No.:M22508-C Receptor occupation and pharmacokinetics ofKi = 10 nM SR 1824 is a non agonist PPAR ligand. Peroxisome proliferator activated receptor (PPAR) can be activated by the anti diabetes drugs known as thiazolidinediones, including rosiglitazone and pioglitazone. Phosphorylation of PPAR by cyclin dependent kinase 5 (Cdk5) leads to dysregulation of genes whose expression is altered in obesity, such as adiponectin. In vitro: In a previous study, SR1824 was characterized for its ability to block Cdk5
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