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Formula: C22H18N4O2S3
This inhibition of MEK1/2 is noncompetitive with ERK and ATP
Ropelle ER
Specificity studies have shown that it has no activity on GLP-2
BG45 - HDAC3 Inhibitor. CAS# 926259-99-6 Catalog No.:M60266-10S Formula: C22H18N4O2S3BG45, CAS No. 926259 99 6, is a potent, selective and cell permeable HDAC3 inhibitor. It inhibits HDAC3 with IC50 of 289 nM. It has IC50 of 2. 0 M, 2. 2 M and >20 M for HDAC1, HDAC2, and HDAC6 in cell free assays, respectively. BG45 triggers significant MM cell growth inhibition via apoptosis, evidenced by caspase and poly (ADP ribose) polymerase cleavage. BG45 alone and in combination with bortezomib triggers significant tumor growth inhibition in