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InChi: InChI=1S/C26H29N7O2/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(24(35)15-34)11-9-21(17)29-23/h4
2 mg/mL (8
Smiles: CC1=CC(OCCCC(C)(C)C(O)=O)=C(C)C=C1
Smiles: CCCC1=CC(=CC=N1)C1=NC(=CS1)C1C=CC(=CC=1)NS(C)(=O)=O
TAE-1 ethylbenzenesulfonate InChi: InChI=1S/C26H29N7O2/c1-16-2-5-18(6-3-16)33-22-13-27-10-8-19(22)20-12-28-26(31-25(20)33)30-23-7-4-17-14-32(24(35)15-34)11-9-21(17)29-23/h4IC50: 0. 3 0. 02 M for AChE; 3. 9 0. 2 M for BuChE TAE 1 is an inhibitor of amyloid fibril formation and aggregation. Alzheimers disease (AD), a progressive neurodegenerative disorder, is characterized by the cerebral accumulation of insoluble aggregates of amyloid peptides (A). Although the precise mechanisms governing neuronal loss remains ambiguous, toxicity resulting from A activated pathways is evident. In vitro: In a previous study, the authors
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