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7)43(53-31(5)59)46(63)57-25-36(60)22-38(57)45(62)51-24-32-8-10-34(11-9-32)42-28(2)52-26-66-42/h8-15
AZD8186 inhibits proliferation of MDA-MB-468 cells with a GI50 value of 65 nM
reveals EC50 value of 0
Smiles: OC(=O)[C@H]1O[C@@H](OC2C=C3SC(=C(C3=CC=2)C(=O)C2C=CC(=CC=2)OCCN2CCCCC2)C2C=CC(O)=CC=2)[C@H](O)[C@@H](O)[C@@H]1O
TC-N 22A Catalog No.:M18602-C 7)43(53-31(5)59)46(63)57-25-36(60)22-38(57)45(62)51-24-32-8-10-34(11-9-32)42-28(2)52-26-66-42/h8-15TC N 22A is a potent, selective, orally active and brain permeable mGlu4 PAM with an EC50 of 9 nM in human mGlu4 expressing BHK cells. TC N 22A is less active (EC50>10 M) in agonist and PAM model at mGlu 1, 2, 3, 5, and 7 receptors. TC N 22A has the potential for research of CNS disease in vivo. Product information CAS Number: 1314140 00 5 Molecular Weight: 283. 35 Formula: C14H13N5S Chemical Name: (4Z) N (pyridin 2 yl) 5 thia 3,11,12
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