Ro 25-6981 Size:Solid 2 mg InChi: InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H

InChi: InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6H

ClH/c32-26-10-6-25(7-11-26)22-36-30-38-29(35-21-24-4-2-1-3-5-24)39-31(40-30)37-27-12-8-23(9-13-27)20-28(41)34-15-17-43-19-18-42-16-14-33

2139348-63-1

and an increased efficacy in vivo compared to either single agent alone

Ro 25-6981 Size:Solid 2 mg InChi: InChI=1S/C14H8O4/c1-7(15)11-6-10-12(16)8-4-2-3-5-9(8)13(17)14(10)18-11/h2-6HRo 25 6981 is a highly potent and selective blocker of N methyl D aspartate receptors containing the NR2B subunit. Ro 25 6981 inhibited 3H MK 801 binding to rat forebrain membranes in a biphasic manner with IC50 values of 0. 003 microM and 149 microM for high (about 60%) and low affinity sites, respectively. NMDA receptor subtypes expressed in Xenopus oocytes were blocked with IC50 values of 0. 009 microM and 52 microM for the subunit combinations