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Formula: C24H24N4O5S
Molecular Weight: 187
PF-06447475 successfully blocks the enhanced neuroinflammation associated with G2019S-LRRK2 expression
irreversible modification of GDP-bound recombinant KRAS G12C and suppresses ERK phosphorylation with an IC50 = 1 nM in the H358 cell line
Lovastatin ndolapril Formula: C24H24N4O5SLovastatin inhibits HMGCR, blocking the enzyme catalyzed transformation of 3 hydroxy 3 methylglutaryl CoA into mevalonate. Lovastatin is a statin natural product isolated from numerous sources including the Pleurotus ostreatus oyster mushroom, demonstrating hypocholesterolemic and antiproliferative properties. The biosynthesis of cholesterol requires mevalonate as a building block and elimination of mevalonate generation subsequently interrupts