THIQ rafenib D3) Chemogenetic Control of Protein Anchoring

Chemogenetic Control of Protein Anchoring to Endomembranes in Living Cells with Lipid-Tethered Small Molecules

Z433927330 is also a partial AQP3 inhibitor (IC50

and provides an antioxidant action either by direct reaction with free radicals or by regeneration of tocopherol and ascorbate from their oxidised state[1]

3-[18-(2-carboxyethyl)-8

THIQ rafenib D3) Chemogenetic Control of Protein AnchoringTHIQ is the first selective agonist of the melanocortin 4 receptor (MC4R), with high affinity and potency for hMC4R (IC50=1. 2 nM, EC50=2. 1 nM) and rMC4R (IC50=0. 6 nM, EC50=2. 9 nM). THIQ maintains low potency at MC1R, MC3R and MC5R. THIQ plays a role in eliciting erectile activity in rodents. THIQ acts as a pharmacoperone of the MC4R rescuing the cell surface expression and signaling of some intracellularly retained MC4R mutants. Product