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InChiKey: NOGGBVNCVONHHC-RVDMUPIBSA-N
Formula: C8H11NO
Smiles: CC(=O)O[C@H]1CC2=CC=CC=C2N(C(N)=O)C2=CC=CC=C21
122(22):3628-31
Volasertib trihydrochloride - CAS# 946161-17-7 bradine Hydrochloride InChiKey: NOGGBVNCVONHHC-RVDMUPIBSA-NVolasertib (BI 6727) trihydrochloride is an orally active, highly potent and ATP competitive Polo like kinase 1 (PLK1) inhibitor with an IC50 of 0. 87 nM. Volasertib trihydrochloride inhibits PLK2 and PLK3 with IC50s of 5 and 56 nM, respectively. Volasertib trihydrochloride induces mitotic arrest and apoptosis. Volasertib trihydrochloride, a dihydropteridinone derivative, shows marked antitumor activity in multiple cancer models. Product information
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