SAG - Hedgehog Agonist. CAS# 912545-86-9 size:2 mg solid InChiKey: RWKUVRQLFRJTTR-UHFFFAOYSA-N

InChiKey: RWKUVRQLFRJTTR-UHFFFAOYSA-N

PBIT was used at 10-30 µM in vitro

(2011) Biochem Pharmacol

BRPF2 (100-fold) and BRPF3 (>1000-fold)

SAG - Hedgehog Agonist. CAS# 912545-86-9 size:2 mg solid InChiKey: RWKUVRQLFRJTTR-UHFFFAOYSA-NSAG, CAS NO. 912545 86 9, is a potent, selective, and cell permeable small molecule agonist of the Hedgehog pathway. It modulates the coupling of Smo with its downstream effector by interacting with the Smo heptahelical domain (KD = 59 nM). SAG induces Hedgehog pathway activation with an EC50 of ~3 nM in NIH 3T3 derived Shh LIGHT2 cells and counteracts Cyclopamine KAAD inhibition of Smo. It was reported that SAG acts as an activator at low