Pay in 4 interest-free payments of $17.25 Learn more
Ships within 48 hours · Estimated delivery Aug 2 - Aug 7
PubMed Central PMCID: PMC5603554
108 nmol/min/mg protein
GSK-3787 has pharmacokinetic properties suitable for use as an in vivo PPARδ antagonist tool compound in mice
13(23):4525-33
MAK-683 - CAS# 1951408-58-4 Catalog No.:M7137-2 PubMed Central PMCID: PMC5603554MAK 683, CAS No. 1951408 58 4, is a potent inhibitor of embryonic ectoderm development protein (EED) and allosteric inhibitor of polycomb repressive complex 2 (PRC2), with potential antineoplastic activity. Upon administration, MAK683 selectively binds to the domain of EED that interacts with trimethylated lysine 27 on histone 3 (H3K27me3), which leads to a conformational change in the EED H3K27me3 binding pocket and prevents the interaction of EED