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Reprogramming of human primary somatic cells by OCT4 and chemical compounds
Environ Health
CAS Number: 925434-55-5
KAN 0438757
SGI-110 Size:Solid 10 mg Reprogramming of human primary somaticGuadecitabine, aslo known as SGI 110, is a dinucleotide antimetabolite of a decitabine linked via phosphodiester bond to a guanosine, with potential antineoplastic activity. Following metabolic activation by phosphorylation and incorporation into DNA, SGI 110 inhibits DNA methyltransferase, thereby causing genome wide and non specific hypomethylation and inducing cell cycle arrest at S phase. This agent is resistant to cytidine deaminase, hence may
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