CB-6644 - CAS# 2316817-88-4 BI-98782 PNRI-299 has no effect on

PNRI-299 has no effect on NF-κB transcription (up to 200 uM) or thioredoxin (up to 200 uM)

and exhibits no inhibition even at 1 mM for PHD2

PubMed PMID: 24804890

Chemical Name: 3-(Dimethylaminomethyl)indole

CB-6644 - CAS# 2316817-88-4 BI-98782 PNRI-299 has no effect onCB 6644 is a novel allosteric selective inhibitor of the ruvbl1 2 complex with anti cancer activity. CB 6644 blocks the ATPase activity of RUVBL1 2 with an IC50 of 15 nM. CB 6644 interacts specifically with RUVBL1 2 in cancer cells, leading to cell death. Importantly, drug acquired resistant cell clones have amino acid mutations in either RUVBL1 or RUVBL2, suggesting that cell killing is an on target consequence of RUVBL1 2 engagement. In xenograft