CP-465022 (maleate) hrin-β 1'-biphenyl]-3-yl]methyl}-3

1'-biphenyl]-3-yl]methyl}-3

Chemical Name: (2S)-2-amino-3-[(2-diazoacetyl)oxy]propanoic acid

Formula: C21H13BrN2O3

268(1):337-52

CP-465022 (maleate) hrin-β 1'-biphenyl]-3-yl]methyl}-3IC50: 25 nM for AMPA receptor mediated currents in rat cortical neurons CP 465022 is an AMPA antagonist. The inhibition of alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid (AMPA) receptor has been hypothesized to lead to neuroprotective efficacy after cerebral ischemia on the basis of the activity in ischemia models of a variety of compounds with varying selectivity for AMPA over other glutamate receptor subtypes. In vitro: CP 465022 inhibited