Pomalidomide-PEG4-Ph-NH2 Catalog No.:M13003-10 [1-3] VX-745 (60 nM-20 µM)

[1-3] VX-745 (60 nM-20 µM) inhibits IL-6 and VEGF secretion in bone marrow stromal cells (BMSCs)

Smiles: CCCC1=NC(=C(C(O)=O)N1CC1C=CC(=CC=1)C1=CC=CC=C1C1=NNN=N1)C(C)(C)O

the structurally similar but ineffective JAK1/2 inhibitors INCB027753 and INCB029843 has no significant effect in any of these assays systems when tested at concentrations up to 10 μM

Formula: C2H8N2O3Pt

Pomalidomide-PEG4-Ph-NH2 Catalog No.:M13003-10 [1-3] VX-745 (60 nM-20 µM)Pomalidomide PEG4 Ph NH2 is a synthesized E3 ligase ligand linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4 unit PEG linker used in PROTAC technology. Product information CAS Number: 1818885 63 0 Molecular Weight: 540. 56 Formula: C27H32N4O8 Chemical Name: 4 [12 (4 aminophenoxy) 4,7,10 trioxa 1 azadodecan 1 yl] 2 (2,6 dioxopiperidin 3 yl) 2,3 dihydro 1H isoindole 1,3 dione Smiles: