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Epub 2016 Oct 25
CAS Number: 909910-43-6
and SUV39H2 etc
sequence analysis and functional characterization of the gene cluster for biosynthesis of K-252a and its analogs
APS-2-79 - CAS# 2002381-25-9 size:2mg solid Epub 2016 Oct 25APS 2 79, CAS No. 2002381 25 9, is a KSR dependent MAPK modulator. APS 2 79 modulates KSR dependent MAPK signalling by antagonizing RAF heterodimerization as well as the conformational changes required for phosphorylation and activation of KSR bound MEK (mitogen activated protein kinase kinase). APS 2 79 increased the potency of several MEK inhibitors specifically within Ras mutant cell lines by antagonizing release of negative feedback signalling,
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