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Fostemsavir
reduces activity of AST and ALT in TCDD-treated mice
AC-55541 was stable to metabolism by liver microsomes and maintained sustained exposure in rats
PubMed PMID: 17962474
EBE-A22 Catalog No.:M10416-10 FostemsavirEBE A22 is a derivative of PD 153035. EBE A22, has no effect on EGF R TK but maintains a high cytotoxic profile. EBE A22 binds to DNA and behave as typical intercalating agents. EBE A22 unwinds supercoiled plasmid, stabilizes duplex DNA against heat denaturation, and produces negative CD and ELD signals, as expected for an intercalating agent. EBE A22, but not PD153035, interacts preferentially with GC rich sequences and discriminates against