ITD-1 - TGFβ inhibitor. CAS# 1099644-42-4 0281 Henderson YC

Henderson YC

Smiles: COC1=CC=CC=C1C(=O)NC1=CC2=C(C=C1N1CCCCC1)N(C)C(=O)N2C

and potential for combination in preclinical models

ML323 inhibits the deubiquitination of PCNA and FANCD2

ITD-1 - TGFβ inhibitor. CAS# 1099644-42-4 0281 Henderson YCITD 1, CAS No. 1099644 42 4, is a novel and highly selective TGF pathway inhibitor identified by a high throughput, embryonic stem cell (ESC) cardiac differentiation screening. ITD 1 promoted cardiomyocyte differentiation specifically via degradation of the TGF type II receptor (TGFBR2), effectively clearing the receptor from the cell surface and selectively inhibiting intracellular signaling (IC50 0. 40. 8 M), revealing a role for TGF signaling