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K-7174 dihydrochloride iophen-2-yl)-2-(2-(m-tolyl)hydrazono)butane-1 3-dione Formula: C23H18ClF2N3O3S

SKU: 25759250429

4.7
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Description

Formula: C23H18ClF2N3O3S

Wogonin (30

although RS-127445 has no significant effect on the visceral nociceptive threshold of native rats

Formula: C14H11N

K-7174 dihydrochloride iophen-2-yl)-2-(2-(m-tolyl)hydrazono)butane-1 3-dione Formula: C23H18ClF2N3O3SK 7174 is a novel orally active, potent proteasome inhibitor. K 7174 exerts anti myeloma activity in vitro and in vivo by down regulating the expression of class I histone deacetylases. K 7174 kills bortezomib resistant myeloma cells carrying a 5 subunit mutation in vivo and primary cells from a patient resistant to bortezomib. K 7174 is also a GATA specific inhibitor, which may have potential application in treating anemia of chronic disease. Product

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