MIRA-1 idinium bromide Chikusetsusaponin 5

Chikusetsusaponin 5

All treated cells exhibits sensitivity to ISCK03 in a dose-dependent manner

and Fe-) of peptide deformylases from both S

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MIRA-1 idinium bromide Chikusetsusaponin 5MIRA 1 is a maleimide derived small molecule that reactivates the tumor suppressor function of mutant p53, inducing apoptosis in several human solid tumor cell lines carrying tetracycline regulated mutant p53 (IC50 = 10 M in vitro). 1 Treatment of tumor cells with MIRA 1 induces p21, MDM2 and PUMA in a mutant p53 dependent manner. At a concentration of 5 10 mg kg, MIRA 1, alone or in combination with dexamethasone , arrested tumor growth in a mouse