PP242 - mTORC1/mTORC2 inhibitor. CAS# 1092351-67-1 size:2 mg solid cytokine production and autoantibody levels

cytokine production and autoantibody levels at well-tolerated doses

99(22):14071-6

Molecular modeling studies of the novel inhibitors of DNA methyltransferases SGI-1027 and CBC12: implications for the mechanism of inhibition of DNMTs

CAS Number: 1675201-83-8

PP242 - mTORC1/mTORC2 inhibitor. CAS# 1092351-67-1 size:2 mg solid cytokine production and autoantibody levelsPP242, CAS No. 1092351 67 1, is a highly potent, selective and ATP competitive mTORC1 mTORC2 inhibitor (IC50 = 8 nM). It has > 10 folds selectivity over the other PI 3K family kinases (IC50 0. 102 M, 0. 408 M, 1. 27 M, 1. 96 M and 2. 2 M for p110, DNA PK, p110, p110 and p110, respectively). Except some weak inhibitory activity against PKC, JAK2, PKCI, PKCII and RET (0. 05 0. 22 M), PP242 exhibits excellent selectivity over 215 other protein kinases.