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is a quinolone-derived sphingomyelin synthase inhibitor that blocks P-glycoprotein and multidrug resistance-associated protein-1
(-)-SNI-2011
2020 Mar 27
Smiles: CN1CCN(CC1)C1=CC(NC2=NC3C4=C(CCC=3C=N2)C(=NN4CCO)C(N)=O)=C(C=C1)OC(F)(F)F
NV-5138 C AR Degrader-4 TFA is a quinolone-derived sphingomyelin synthaseNV 5138 is an orally and centrally active small molecule drug for the treatment of major depressive disorder (MDD). It directly and selectively activates the mammalian target of rapamycin complex 1 (mTORC1) signaling pathway by binding to and modulating sestrin2, a leucine amino acid sensor and upstream regulatory pathway. The mTORC1 pathway is the same signaling pathway that the NMDA receptor antagonist ketamine activates in the medial prefrontal
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