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including LDL apheresis where available for the reduction of LDL-C
Targeting myocardial remodelling to develop novel therapies for heart failure: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology
CAS Number: 856243-80-6
EMCS Crosslinker
TEPP-46 (ML265) - Pyruvate Kinase M2 (PKM2) Activator. CAS# 1221186-53-3 60123 including LDL apheresis where availableTEPP 46 (ML265), CAS No. 1221186 53 3, is a potent and selective Pyruvate kinase M2 (PKM2) activator with EC50 ~92 nM. It demonstrates >100 fold selectivity for PKM2 over the related PKM1, PKR, and PKL isoforms. It can stabilize pyruvate kinase subunit interactions, promote PKM2 tetramer formation and prevent inhibition by phosphotyrosine signaling. It can alter metabolism in cultured cells, and inhibit xenograft tumor growth in vivo. TEPP 46 inhibits
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