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1007/s10549-010-1247-7
Mice treated with TOK-001 have smaller average tumor volume on day 31 when compared to control (p= 0
2013 Oct 8
780 and 1940 nM for ROCK1
DMH-1 - CAS# 1206711-16-1 60251 1007/s10549-010-1247-7DMH 1, CAS No. 1206711 16 1, is a second generation small molecule BMP inhibitor based on dorsomorphin. DMH 1 effectively inhibits the bone morphogenic protein (BMP) ALK2 receptor (IC50 = 108 nM). Treatment with DMH1 reduced lung metastasis and the tumors were less proliferative and more apoptotic. In the surrounding tumor microenvironment, treatment with DMH1 altered fibroblasts, lymphatic vessels and macrophages to be less tumor promoting. These
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