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In PK analysis
LDN-211904 demonstrated the best stability with a t1/2 of 348 min and a CLint of 4 μL/min/mg protein
Formula: C17H16FN3
18)19/h4-9
tumor protein p53 binding protein fragment [Homo sapiens]/[Mus musculus] stimate In PK analysisP53 is a sequence specific DNA binding oligomeric protein that can activate transcription from promoters bearing p53 binding sites. Whereas the activation region of p53 has been identified within the amino terminus, the location of the specific DNA binding domain has not been reported1. Tumor protein p53 binding protein (53BP1) has been identified in a yeast two hybrid screen as a protein that interacts with the central DNA binding domain of p532.