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heterobifunctional small-molecule BET degraders have been designed based upon the proteolysis targeting chimera (PROTAC) concept to induce BET protein degradation
Smiles: C=CC(=O)NC1=CC2=C(NC3=CC(Cl)=C(F)C=C3)N=CN=C2C=C1OCCCN1CCOCC1
allowing conditional expression of mtFKBP-fused proteins
KB-R7943 dose-dependently inhibits NMDA-induced increases in [Ca2+]c with IC50=13
7-Acetylintermedine - CAS# 74243-01-9 instat hydrochloride heterobifunctional small-molecule BET degraders have7 Acetylintermedine is a hepatotoxic botanical pyrrolizidine alkaloid. Product information CAS Number: 74243 01 9 Molecular Weight: 341. 40 Formula: C17H27NO6 Chemical Name: [(1R,7aR) 1 (acetyloxy) 2,3,5,7a tetrahydro 1H pyrrolizin 7 yl]methyl (2S) 2 hydroxy 2 [(1R) 1 hydroxyethyl] 3 methylbutanoate Smiles: CC(=O)O[C@@H]1CCN2CC=C(COC(=O)[C@@](O)([C@@H](C)O)C(C)C)[C@@H]21 InChiKey: RKDOFSJTBIDAHX CYHLAULCSA N InChi: InChI=1S C17H27NO6 c1
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