Dacomitinib itein Chemical Name: N-(6

Chemical Name: N-(6

Smiles: CN1CCN(CC1)C1CCC(CC1)N1C=C(C2=C(N)N=CN=C12)C1C=CC(=CC=1)OC1C=CC=CC=1

CAS Number: 1159101-48-0

Semaxanib reversibly inhibits ATP binding to the tyrosine kinase domain of vascular endothelial growth factor receptor 2 (VEGFR2)

Dacomitinib itein Chemical Name: N-(6Dacomitinib, also known as PF 299 and PF 00299804 ; or PF299804, is an orally bioavailable, highly selective, second generation small molecule inhibitor of the pan epidermal growth factor receptor (EGFR) family of tyrosine kinases (ErbB family) with potential antineoplastic activity. Dacomitinib specifically and irreversibly binds to and inhibits human EGFR subtypes, resulting in inhibition of proliferation and induction of apoptosis in EGFR