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A small molecule (pluripotin) as a tool for studying cancer stem cell biology: proof of concept
in mice induces a rapid Akt phosphorylation readily detectable in lung lysates
High-fat diet-fed C57BL/6J mice develop hyperglycaemia and impair glucose tolerance
InChiKey: QAPAJIZPZGWAND-UHFFFAOYSA-N
ATI-2341 631T-9010 tetrasodium A small molecule (pluripotin) asATI 2341 is a potent and functionally selective allosteric agonist of C X C chemokine receptor type 4 (CXCR4), which functions as a biased ligand, favoring Gi activation over G13. ATI 2341 activates the inhibitory heterotrimeric G protein (Gi) to promote inhibition of cAMP production and induce calcium mobilization. ATI 2341 is a potent and efficacious mobilizer of bone marrow polymorphonuclear neutrophils (PMNs) and hematopoietic stem and progenitor
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