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PF-04620110 Catalog No.:M10806-2 SAR-20347 inhibits TYK2- and JAK1-mediated

SKU: 40878674226

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Description

SAR-20347 inhibits TYK2- and JAK1-mediated IL-12 and IFN-α signaling

PF-04620110 Catalog No.:M10806-2 SAR-20347 inhibits TYK2- and JAK1-mediatedPF 04620110 is an orally active, selective and potent DGAT1 (Acyl CoA: diacylglycerol acyltransferase 1) inhibitor that inhibits triacylglycerol synthesis in cells and in rodents. F 04620110 inhibits DGAT 1 with an IC50 of 19 nM and shows high selectivity versus a broad panel of off target pharmacologic end points. In vivo DGAT 1 inhibition has been demonstrated through reduction of plasma triglyceride levels in rodents at doses of 0. 1 mg kg

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