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(2012) Genes Dev
23(1):131-8
Degrasyn activates proteasomal-dependent degradation of c-Myc
A Novel Anti-inflammatory Role of GPR120 in Intestinal Epithelial Cells
GSK2801 - Bromodomain BAZ2A/B Inhibitor. CAS# 1619994-68-1 size:2 mg solid (2012) Genes DevGSK2801, CAS No. 1619994 68 1, is a potent, selective and cell permeable inhibitor of the bromodomain BAZ2A and BAZ2B. It binds to BAZ2 bromodomains with dissociation constants (KD) of 136 and 257 nM for BAZ2B and BAZ2A, respectively. Crystal structures of GSK2801 demonstrated a canonical acetyl lysine competitive binding mode. It does not interact with the bromodomains of BRD4(BD1), CREBBP, TRIM24 TIF1, PB1(BD5), PCAF, or ATAD2. A pharmacokinetic
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