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Triapine causes a significant increase (1
]hexatriaconta-3
∼50 and ∼50 nM for PARP1
WO 2018057618 A1
TX1-85-1 cium) Triapine causes a significant increaseTX1 85 1 is an irreversible Her3 (ErbB3) inhibitor with an IC50 of 23 nM. TX1 85 1 is also the first selective Her3 ligand, which forms a covalent bond with Cys721 located in the ATP binding site of Her3. TX1 85 1 induces partial degradation of Her3 protein and attenuates Her3 dependent signaling. Product information CAS Number: 1603845 32 4 Molecular Weight: 580. 68 Formula: C32H36N8O3 Chemical Name: N (5 {1 [4 (4 acetylpiperazin 1 yl)cyclohexyl] 4
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