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TAME at concentration of 200 μM dramaticly inhibits the ubiquitin ligase activity of the Anaphase-Promoting Complex (APC)
2019 Aug 20:1-4
EPZ-6438 was orally dosed to mice at 250-500 mg/kg twice per day for 21-28 days
CAS Number: 1356962-34-9
Gliotoxin Size:10mg solid TAME at concentration of 200Gliotoxin is a secondary metabolite, the most abundant mycotoxin secreted by A. fumigatus, inhibits the phagocytosis of macrophages and the immune functions of other immune cells. Gliotoxin inhibits inducible NF B activity by preventing IB degradation, which consequently induces host cell apoptosis. Gliotoxin activates PKA and increases intracellular cAMP concentration; modulates actin cytoskeleton rearrangement to facilitate A. fumigatus
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