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a target biomarker of MK2 activity
InChiKey: WOWDZACBATWTAU-FEFUEGSOSA-N
CCG215022 has nanomolar potency against both GRK2 and GRK5 and is at least 20-fold more potent than Paroxetine
Marı A Maneiro
CCG-50014 Size:Contact [email protected] for quotation a target biomarker of MK2CCG 50014 is the most potent against the regulator of G protein signaling protein type 4 (RGS4) (IC50 =30 nM) and is >20 fold selective for RGS4 over other RGS proteins. CCG 50014 binds covalently to the RGS, forming an adduct on two cysteine residues located in an allosteric regulatory site. CCG50014, reduces nociceptive responses and enhances opioid mediated analgesic effects in the mouse formalin test. Product information CAS Number: 883050 24 6
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