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InChi: InChI=1S/C14H7ClFN3O5/c15-10-5-7(1-3-11(10)16)18-14(21)9(13(20)17-18)6-8-2-4-12(24-8)19(22)23/h1-6H
4SC-202 has very high selectivity over ClassIIa/IIb/III HDACs
27(3):275-80
is a potent and selective and orally active PRMT5 inhibitor with a half-maximal inhibitory concentration (IC50) of 22 nM and broad selectivity against a panel of other histone methyltransferases
Rapamycin - mTOR inhibitor. CAS# 53123-88-9 size:2mg solid InChi: InChI=1S/C14H7ClFN3O5/c15-10-5-7(1-3-11(10)16)18-14(21)9(13(20)17-18)6-8-2-4-12(24-8)19(22)23/h1-6HRapamycin, CAS No. 53123 88 9, is a potent and selective mTOR inhibitor. Rapamycin, in complex with the cytosolic protein FK binding protein 12 (FKBP12), inhibits mTOR Complex 1 (mTORC1) by binding to the FRB domain of mTor. Given the central roles mTor plays, Rapamycin showed diverse activities, including anti proliferative effects in cancer cells, immunosuppressive effect, lifespan extension in mice, improved cognition in the mouse model of autism
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