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Ixazomib for the treatment of multiple myeloma
is approximately 40%
5 µM in vitro and cellular assays
Epub 2007 Sep 26
OSI-027 - mTOR Inhibitor. CAS# 936890-98-1 Catalog No.:M60113-10S Ixazomib for the treatment ofOSI 027, CAS No. 936890 98 1, is a selective and potent dual inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. It shows more than 100 fold selectivity for mTOR relative to PI3K, PI3K, PI3K, and DNA PK. It inhibits phosphorylation of the mTORC1 substrates 4E BP1 and S6K1 as well as the mTORC2 substrate AKT in diverse cancer models in vitro and in vivo. OSI 027 shows robust antitumor activity in several different human xenograft
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