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Chemical Name: 2-((4-chlorophenyl)sulfonyl)-4-methoxy-1-nitrobenzene
is a MRCK inhibitor
while high concentrations (1-3 g/L) produces a pronounced vasodilator after a transient vasocontraction
CPI-637 inhibits MYC expression in AMO-1 cells (EC50 = 0
ML314 P-6 Chemical Name: 2-((4-chlorophenyl)sulfonyl)-4-methoxy-1-nitrobenzeneML 314 is a brain penetrant nonpeptidic arrestin biased ggonist of the neurotensin NTR1 receptor, which exhibits full agonist behavior against NTR1 (EC50 = 2. 0 M) in the primary assay and selectivity against NTR2. The effect of ML314 is blocked by the NTR1 antagonist SR142948A in a dose dependent manner. Unlike peptide based NTR1 agonists, ML314 has no significant response in a Ca2+ mobilization assay and is thus a biased agonist that activates the